Nanoparticle‐based luminescent probes for intracellular sensing and imaging of pH
Identifieur interne : 000E02 ( Main/Exploration ); précédent : 000E01; suivant : 000E03Nanoparticle‐based luminescent probes for intracellular sensing and imaging of pH
Auteurs : Michael Sch Ferling [Allemagne]Source :
- Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology [ 1939-5116 ] ; 2016-05.
Abstract
Fluorescence imaging microscopy is an essential tool in biomedical research. Meanwhile, various fluorescent probes are available for the staining of cells, cell membranes, and organelles. Though, to monitor intracellular processes and dysfunctions, probes that respond to ubiquitous chemical parameters determining the cellular function such as pH, pO2, and Ca2+ are required. This review is focused on the progress in the design, fabrication, and application of photoluminescent nanoprobes for sensing and imaging of pH in living cells. The advantages of using nanoprobes carrying fluorescent pH indicators compared to single molecule probes are discussed as well as their limitations due to the mostly lysosomal uptake by cells. Particular attention is paid to ratiometric dual wavelength nanosensors that enable intrinsic referenced measurements. Referencing and proper calibration procedures are basic prerequisites to carry out reliable quantitative pH determinations in complex samples such as living cells. A variety of examples will be presented that highlight the diverseness of nanocarrier materials (polymers, micelles, silica, quantum dots, carbon dots, gold, photon upconversion nanocrystals, or bacteriophages), fluorescent pH indicators for the weak acidic range, and referenced sensing mechanisms, that have been applied intracellularly up to now. WIREs Nanomed Nanobiotechnol 2016, 8:378–413. doi: 10.1002/wnan.1366 For further resources related to this article, please visit the WIREs website.
Url:
DOI: 10.1002/wnan.1366
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001F46
- to stream Istex, to step Curation: 001F46
- to stream Istex, to step Checkpoint: 000021
- to stream Main, to step Merge: 000E03
- to stream Main, to step Curation: 000E02
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nanoparticle‐based luminescent probes for intracellular sensing and imaging of pH</title><author><name sortKey="Sch Ferling, Michael" sort="Sch Ferling, Michael" uniqKey="Sch Ferling M" first="Michael" last="Sch Ferling">Michael Sch Ferling</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E7B00A756C07DF00B0BC4E28A655CFB4B674623</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1002/wnan.1366</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-CD0B0TF8-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001F46</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001F46</idno><idno type="wicri:Area/Istex/Curation">001F46</idno><idno type="wicri:Area/Istex/Checkpoint">000021</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000021</idno><idno type="wicri:doubleKey">1939-5116:2016:Sch Ferling M:nanoparticle:based:luminescent</idno><idno type="wicri:Area/Main/Merge">000E03</idno><idno type="wicri:Area/Main/Curation">000E02</idno><idno type="wicri:Area/Main/Exploration">000E02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Nanoparticle‐based luminescent probes for intracellular sensing and imaging of pH
</title><author><name sortKey="Sch Ferling, Michael" sort="Sch Ferling, Michael" uniqKey="Sch Ferling M" first="Michael" last="Sch Ferling">Michael Sch Ferling</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division 1.10 Biophotonics, Federal Institute for Materials Research and Testing, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology</title><title level="j" type="alt">WILEY INTERDISCIPLINARY REVIEWS: NANOMEDICINE AND NANOBIOTECHNOLOGY</title><idno type="ISSN">1939-5116</idno><idno type="eISSN">1939-0041</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="378">378</biblScope><biblScope unit="page" to="413">413</biblScope><biblScope unit="page-count">1</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>Hoboken, USA</pubPlace><date type="published" when="2016-05">2016-05</date></imprint><idno type="ISSN">1939-5116</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1939-5116</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Fluorescence imaging microscopy is an essential tool in biomedical research. Meanwhile, various fluorescent probes are available for the staining of cells, cell membranes, and organelles. Though, to monitor intracellular processes and dysfunctions, probes that respond to ubiquitous chemical parameters determining the cellular function such as pH, pO2, and Ca2+ are required. This review is focused on the progress in the design, fabrication, and application of photoluminescent nanoprobes for sensing and imaging of pH in living cells. The advantages of using nanoprobes carrying fluorescent pH indicators compared to single molecule probes are discussed as well as their limitations due to the mostly lysosomal uptake by cells. Particular attention is paid to ratiometric dual wavelength nanosensors that enable intrinsic referenced measurements. Referencing and proper calibration procedures are basic prerequisites to carry out reliable quantitative pH determinations in complex samples such as living cells. A variety of examples will be presented that highlight the diverseness of nanocarrier materials (polymers, micelles, silica, quantum dots, carbon dots, gold, photon upconversion nanocrystals, or bacteriophages), fluorescent pH indicators for the weak acidic range, and referenced sensing mechanisms, that have been applied intracellularly up to now. WIREs Nanomed Nanobiotechnol 2016, 8:378–413. doi: 10.1002/wnan.1366 For further resources related to this article, please visit the WIREs website.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Sch Ferling, Michael" sort="Sch Ferling, Michael" uniqKey="Sch Ferling M" first="Michael" last="Sch Ferling">Michael Sch Ferling</name></region><name sortKey="Sch Ferling, Michael" sort="Sch Ferling, Michael" uniqKey="Sch Ferling M" first="Michael" last="Sch Ferling">Michael Sch Ferling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E02 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E02 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1E7B00A756C07DF00B0BC4E28A655CFB4B674623
|texte= Nanoparticle‐based luminescent probes for intracellular sensing and imaging of pH
}}
| This area was generated with Dilib version V0.6.33. |  |